ANKMJ
Ankyra Medical Journal

Ankyra Medical Journal (AnkMJ), formerly known as the Journal of Translational and Practical Medicine, regularly publishes international quality issues in the field of Medicine in the light of current information.

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Effect of mesterolone on genitourinary system symptoms
Abstract
Androgen replacement therapy may bring varying impacts on genitourinary system symptoms. Despite being a popular molecule used in this therapy, mesterolone is an androgen preparation whose biological effects are not well elucidated. It also has significant advantages over other androgens; for example, it has no liver toxicity, does not aromatize with estrogen and suppress gonadotropins, and has an undetectable toxic dose. It binds to sex hormone binding globulin (SHBG) with high affinity, increasing free testosterone fractions and suppressing SHBG levels. It also exerts anti-estrogenic effects. It has been utilized for infertility as it increases the sperm count, revealing partial benefits. Yet, its impacts on the prostate, lipid profile, and metabolic parameters have not markedly been explored. It is expected to have a neutral effect on the prostate as it has a dihydrotestosterone (DHT)-like effect.

Keywords : Androgen replacement therapy, hypogonadism therapy, testosterone, prostate/drug effects

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Article available in :
Volume 1, Issue 2, 2022
Page : 61-64
https://doi.org/10.51271/JTPM-0002
Article Information
Received : 21 Mar 2022
Accepted : 07 Tem 2022
Published : 30 Eyl 2022
Corresponding Author :

Harun Düğeroğlu: Department of Internal Medicine, Ordu University Training and Research Hospital, Ordu, Turkiye

[email protected]
Citation : Düğeroğlu H. Effect of mesterolone on genitourinary system symptoms. J Transl Pract Med 2022; 1(2): 61-64.

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